Stress, Anxiety and Insomnia: the DIfunctional triad with a high psychophysical impact

Chronic stress is a complex and multifactorial condition in which the body, subjected to prolonged stimuli perceived as stressful, maintains persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis. This results in excessive production of cortisol , the stress hormone, which profoundly alters neuroendocrine balance. It promotes systemic inflammation and compromises the regulation of mood, sleep, and cognitive function.

It is estimated that over 30% of the European adult population suffers from stress-related symptoms, with a particularly high incidence in those exposed to intense cognitive loads, shift workers, and those most vulnerable to hormonal imbalances, such as women of childbearing age or menopausal women.

Among the most common and disabling complications is insomnia , with a prevalence of 20-30% in Europe, and even higher rates in Asia and the Gulf States, where over 35% of adults experience persistent sleep disturbances. The comorbidity of stress, anxiety, and insomnia is well documented in the literature and tends to manifest itself cyclically, progressively worsening the overall psychophysical state of those who suffer from it.

Symptoms associated with chronic stress include irritability, mental fatigue, muscle tension, difficulty concentrating, tachycardia and changes in appetite. On a psychic level, a state of generalized anxiety, with hyperactivation of the sympathetic nervous system, reduction of GABAergic inhibition and imbalances in serotonin and dopamine levels.
The insomnia It often represents the first alarm bell and can manifest itself in three distinct forms:

• Initial: difficulty falling asleep
• Centrale: frequent night awakenings
• terminal: early awakening with inability to fall back asleep

Chronic sleep deprivation impairs cognitive function, alters emotional stability, and weakens the immune system. In the long term, it is associated with an increased risk of developing major depression, hypertension, metabolic syndrome, and neurocognitive decline.

T – Relaxfast^®: natural support for managing stress, anxiety and sleep disorders

T-Relaxfast® ^is a food supplement in capsule form based on Ashwagandha KSM-66® ^, Jujube (Ziziphus jujuba), L-Tryptophan, and liposomal Melatonin (Liposovit® ⁾ , designed to support psycho-physical balance in situations of chronic stress, anxiety, and insomnia . The synergistic action of active ingredients with adaptogenic, anxiolytic, and chronobiological effects makes it a complete, effective, and well-tolerated formulation, even for prolonged use.

KSM-66^® is a patented extract from the root of Withania somnifera, obtained with full-spectrum technology and standardized to 5% in withanolides. It is one of the most studied Ashwagandha extracts in the world, with over 20 randomized clinical trials.
Its main benefits are:

• Cortisol reduction: two randomized double-blind studies have demonstrated a reduction of up to -28% serum cortisol after 60 days of intake (600 mg/day), with a significant improvement in PSS and DASS scores.
• Effectiveness on anxiety and sleep: improved quality of sleep, reduced sleep latency, increased alertness upon awakening.
• Complete adaptogenic action: improves tolerance to physical, cognitive and emotional stressors, acting on the HPA axis without causing sedation or hypnosis.

The dry extract of Ziziphus jujuba , standardized to 2% triterpene saponins , is known for its sedative and anxiolytic properties, documented in traditional Chinese medicine and supported by clinical studies. Its main benefits are:

• Interaction with GABA-A receptors: saponins act as allosteric modulators, promoting natural sedation, without tolerance or dependence.
• Calming and relaxing effect: reduces mental hyperactivity, improves sleep induction and promotes a greater depth of night rest.

L-Tryptophan is an essential amino acid that is the main substrate for the synthesis of serotonin (5-HT) and subsequently melatonin , which modulate mood, emotional stability, and sleep quality. The main benefits of L-Tryptophan are:

• Improving emotional well-being: acts as a natural support for mood regulation and anxiety reduction, promoting a stable state of relaxation.
• Functional synergy: increases the physiological production of melatonin, supporting a physiological and coordinated sleep-wake rhythm.

Liposovit® ^- Melatonin is a patented liposomal formulation that improves the stability, absorption, and bioavailability of melatonin thanks to its encapsulation in natural phospholipids . Its main benefits are:

• Rapid and prolonged action: reduces the time it takes to fall asleep and improves sleep latency, with controlled release and prolonged effect throughout the night.
• Optimized gastrointestinal absorption: overcomes the digestive barriers common to conventional forms, ensuring greater efficacy at physiological dosages.
• High tolerability: promotes natural and regenerating sleep without causing residual drowsiness or rebound effects.

Why choose T – RELAXFAST^®?

• Natural regulation of cortisol and stress. Thanks to the presence of Ashwagandha KSM-66^®, T-RELAXFAST^® contributes in a documented way to the reduction of serum cortisol levels, rebalancing the neuroendocrine response to stressful stimuli. It promotes greater psychophysical resilience and helps prevent the long-term consequences of chronic stress on mood, cognitive performance and the immune system.
• Anxiolytic and calming support without sedation. The titrated extract of Jujube (Ziziphus jujuba) interacts with GABA-A receptors, exerting an anxiolytic and stabilizing effect without residual drowsiness. It reduces mental restlessness, promoting a state of calm and relaxation without compromising lucidity.
• Optimizing mood and sleep-wake cycle: The L-Tryptophan stimulates the physiological production of serotonin and melatonin, two central neurotransmitters in the regulation of mood and sleep. Its synergistic action with Jujube and Melatonin improves emotional tone and promotes a deeper and more regenerating sleep.
• Rapid, deep and physiological sleep: Thanks to Liposovit liposomal technology^®, the melatonin is absorbed optimally and released progressively. This results in a reduced sleep latency, greater continuity of rest and a better quality of awakening, without rebound effects or daytime sleepiness.
• Solid clinical evidence: Randomized, double-blind studies demonstrate that taking Ashwagandha KSM-66^® for 60 days reduces perceived stress by 44%, lowers serum cortisol by 28%, and significantly improves anxiety and insomnia scores. The effect is dose-dependent and well tolerated.
• Safe and highly tolerated formula: T-RELAXFAST^® è gluten and lactose free, also suitable for people with food intolerances. Its phytotherapeutic formulation allows a daily and continuous use, without significant side effects or addiction phenomena.

Average contents Per daily dose 2 capsules

AVERAGE ANALYSIS FOR 2 CAPSULES:

INGREDIENTS
Ashwagandha KSM66^® Ashwagandha root extract (Withania somnifera L. Dunal.), L-Tryptophan; capsule shell: vegetable gelatin; Jujube (Ziziphus jujuba Mill.) es 2% triterpenic saponins; Liposovit^®-Melatonin (of which melatonin; bulking agents: gum arabic, glycerol, sunflower lecithin, phospholipid; antioxidant: DL-alpha-tocopherol); bulking agent: maltodextrin; anti-caking agents: magnesium stearate, corn starch.